Two sample MR report
HLA-DQA2_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 26 | -0.0039026 | 0.0122491 | 0.7527861 |
| Weighted median | 26 | 0.0146884 | 0.0029221 | 0.0000005 |
| Inverse variance weighted | 26 | 0.0119826 | 0.0021089 | 0.0000000 |
| Simple mode | 26 | 0.0157551 | 0.0046941 | 0.0025266 |
| Weighted mode | 26 | 0.0153789 | 0.0050935 | 0.0057642 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 21.89676 | 24 | 0.5854289 |
| Inverse variance weighted | 23.62993 | 25 | 0.5408299 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0204832 | 0.0155588 | 0.2004409 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003583 | 0 | TRUE | 0.0734014 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
